Morphological analysis of HFSC-treated wounds exhibited accelerated wound closure. Flow cytometry analysis showed that HFSC were CD34 positive and nestin positive, but K15 negative. Animals were sacrificed at 3, 7, or 14 days after surgery, and were used for the following histological analyses. Wound healing was recorded with digital photographs. A full-thickness excisional wound model was created and DiI-labeled HFSC were injected around the wound bed. Hair follicle stem cells were obtained from rat vibrissa and labeled with DiI (Invitrogen, Carlsbad, CA), then special markers were detected using flow cytometry. This study examined the effects of adult bulge hair follicle stem cells (HFSC) in wound healing. One appropriate source of stem cells for therapeutic use is stem cells from the adult bulge of hair follicles. Cell therapy is an innovative technique that can be applied to wound healing. Skin wound healing is a serious clinical problem especially after surgery and severe injury of the skin. Heidari, Fatemeh Yari, Abazar Rasoolijazi, Homa Soleimani, Mansoureh Dehpoor, Ahmadreza Sajedi, Nayereh Joulai Veijouye, Sanaz Nobakht, Maliheh PMID:29026781īulge Hair Follicle Stem Cells Accelerate Cutaneous Wound Healing in Rats. Also the differences between mouse and human hair follicles are investigated. Conclusion: The current review discuss about bulge stem cells characteristics and biology including their cycle, location, plasticity, specific markers and regenerative nature. Bulge cell populations, due to their plasticity nature are able to differentiate into distinct linage and could contribute in tissue regeneration. Stem cells isolated from bulge region are label retaining and slow cycling hence these cells are defined as label-retaining cells. Specific markers allow the bulge cells to be isolated from mouse or human hair follicle. Results: Bulge stem cells are pluripotent with high proliferative capacity. Methods: Data were collected using databases and resources of PubMed, Web of Science, Science Direct, Scopus, MEDLINE and their references from the earliest available published to identify English observational studies on hair follicle bulge region. Bulge region is located between the opening of sebaceous gland and the attachment site of the arrector pili muscle. Most of the hair follicle stem cells are reside in niche called bulge. JOULAI VEIJOUYE, Sanaz YARI, Abazar HEIDARI, Fatemeh SAJEDI, Nayereh GHOROGHI MOGHANI, Fatemeh NOBAKHT, Malihehīackground: Hair follicle stem cells exist in different sites. Bulge Region as a Putative Hair Follicle Stem Cells Niche: A Brief Review
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